Research and analysis
Table 3c: Prenatal Growth Restriction
Updated 7 January 2021
Download CSV 5 KB
| Prenatal Growth Retardation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Not set | Carbamazepine | Gabapentin | Lamotrigine | Levetiracetam | Oxcarbazepine | Phenobarbital | Phenytoin | Pregabalin | Topiramate | Valproate | Zonisamide |
| Meta-analyses | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Veroniki et al 2017a | OR 1.15 (0.77,1.67) | OR 1.37 (0.44,3.61) | OR 0.90 (0.56,1.42) | OR 1.27 (3.04,3.54) | OR 0.99 (0.56, 1.76) | OR 1.88 (1.07,3.32) | OR 0.68 (0.37,1.21) | - | OR 2.64 | 1.28 (0.86,1.95) | - |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | (1.41, 4.63) | Not set | Not set |
| Not set | N=2897 | N=70 | N=2882 | N=81 | N=1002 | N=400 | N=519 | Not set | Not set | N=1622 | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=472 | Not set | Not set |
| Pregnancy Registries | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| North | Not set | aRR 1.2 (95% CI 0.7 to 2.0) | Not set | Not set | Not set | aRR 2.4 (95% CI 1.6 to 3.6) | aRR 0.8 (95% CI 0.5 to 1.25) | Not set | aRR 2.4 | Not set | aRR 1.9 (95% CI 1.2 to 3.0) |
| American | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | (95% CI 1.8 to 3.1) | Not set | Not set |
| Hernandez Diaz et al 2017 | Not set | N=153 | Not set | Not set | Not set | N=178 | N=383 | Not set | Not set | Not set | N=125 |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=394 | Not set | Not set |
| Compared with LMT | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| ?Hernandez-Diaz et al 2014 | - | - | 6.8% SGA | - | - | - | - | - | 17.9% SGA | - | 12.2% SGA |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| TPM and ZNS compared with LMT and unexposed control group | Not set | Not set | N=1581 | Not set | Not set | Not set | Not set | Not set | Mean lower BW of 221g | Not set | Mean lower BW of 202g |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Mean lesser birth length of 1cm | Not set | Mean lesser birth length of 1cm |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=347 | Not set | N=98 |
| Birth Registers | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Margulis et al 2019 | BW | - | ref | BW | - | - | - | BW | - | BW | Not set |
| Swedish | -69 (95% CI -112 to -26) | Not set | Not set | -79 (95% CI -166 to 8) | Not set | Not set | Not set | -83 (95% CI -63 to 3) any time | Not set | -27 (95% CI -79 to 24) any time | Not set |
| Not set | any time | Not set | Not set | any time | Not set | Not set | Not set | -127 (95 % CI -210 to 44) 1st trimester | Not set | -40 (95 % CI -95 to 14) 1st trimester | Not set |
| BW (grams) | -87 (95 % CI -133 to -40) 1st trimester use | Not set | Not set | -95 (95 % CI -189 to 2) | Not set | Not set | Not set | N=528 (any time) | Not set | N=992 any time | Not set |
| Not set | N=1988 (any time) | Not set | Not set | 1st trimester | Not set | Not set | Not set | N=489 (1st trimester) | Not set | N=852 1st trimester | Not set |
| Not set | N=1699 (1st trimester) | Not set | Not set | N=215 (any time) | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | N=186 (1st trimester) | Not set | Not set | Not set | Microcephaly | Not set | Microcephaly | Not set |
| Not set | Microcephaly | Not set | Not set | Not set | Not set | Not set | Not set | -0.0 (95% CI -0.3 to 0.2) any time | Not set | -0.2 (95% CI -0.3 to 0.0) any time | Not set |
| Not set | -0.3 (95% CI -0.5 to -0.2) | Not set | Not set | Microcephaly | Not set | Not set | Not set | -0.2 (95% CI -0.4 to -0.1) 1st trimester | Not set | -0.2 (95% CI -0.4 to 0.2) 1st trimester | Not set |
| Not set | any time | Not set | Not set | -0.2 (95% CI -0.5 to 0.0) any time | Not set | Not set | Not set | Not set | Not set | N=931 (any time) | Not set |
| Not set | -0.4 (95% CI -0.6 to -0.3) 1st trimester | Not set | Not set | -0.3 (95% CI -0.6 to 0.0) 1st trimester | Not set | Not set | Not set | N=516 (any time) | Not set | N=802 (1st trimester) | Not set |
| Not set | N=1883 (any time) | Not set | Not set | N=206 (any time) | Not set | Not set | Not set | N=480 (1st trimester) | Not set | Not set | Not set |
| Not set | N= 1605 (1st trimester) | Not set | Not set | N=178 (1st trimester) | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Microcephaly – Birth Head circumference (cm) | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Danielsson et al 2019 | 2.90% | - | 1.80% | 3.40% | - | - | - | - | - | 2.30% | - |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| SGA | N=243 | Not set | N=437 | N=118 | Not set | Not set | Not set | Not set | Not set | N=130 | Not set |
| ?Veiby et al 2014 | SGA BW | - | SGA BW | SGA BW | - | - | - | - | SGA-BW | SGA BW | Not set |
| Not set | 11.90% | Not set | OR1.0 NS (CI not provided) | OR0.8 NS (CI not provided) | Not set | Not set | Not set | Not set | 25.0% vs 8.9% | OR 0.9 NS (CI not provided) | Not set |
| SGA BW | Vs | Not set | Not set | Not set | Not set | Not set | Not set | Not set | aOR 3.29 (95% 1.70 to 6.39) | Not set | Not set |
| Not set | 9.60% | Not set | SGA HC | SGA HC | Not set | Not set | Not set | Not set | Not set | SGA HC | Not set |
| Not set | aOR 1.37 (95% 1.09 to 1.73) | Not set | OR 1.1 NS (CI not provided) | OR 0.4 NS (CI not provided) | Not set | Not set | Not set | Not set | SGA-HC | OR 0.8 NS (CI not provided) | Not set |
| SGA HC | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | 14.9% vs 2.4% | Not set | Not set |
| Not set | SGA HC | Not set | N=983 | N=188 | Not set | Not set | Not set | Not set | aOR 7.21 (95% CI 3.23 to 16.1) | N=410 | Not set |
| Not set | 4.60% | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Vs | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=90 | Not set | Not set |
| Not set | 2.40% | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | aOR 2.05 (95% 1.44 to 2.93) | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | N=704 | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Killic et al 2014 | SGA | SGA | SGA | SGA | SGA | SGA | SGA | SGA | SGA | SGA | Not set |
| Not set | 13.5% (all) | 12.1% (all) | 10.3% (all) | 15.3% (all) | 18.7% (all) | 18.9% (all) | 38.5% (all) | 27.8% (all) | 23.3% (all) | 16.8% (all) | Not set |
| SGA | 11.2% (mono) | 12.5% (mono) | 8.9% (mono) | 11.5% (mono) | 16.0% (mono) | 18.8% (mono) | 20.0% (mono) | 23.1% (mono) | 17.0% (mono) | 15.3% (mono) | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| LBW | LBW | LBW | LBW | LBW | LBW | LBW | LBW | LBW | LBW | LBW | Not set |
| Not set | 6.5% (all) | 5.5% (all) | 5.8% (all) | 5.6% (all) | 6.2% (all) | 9.9% (all) | 7.7% (all) | 16.7% (all) | 5.4% (all) | 8.1% (all) | Not set |
| Not set | 6.6% (mono) | 6.9% (mono) | 5.5% (mono) | 7.7% (mono) | 5.5% (mono) | 9.4% (mono) | 20.0% (mono) | 15.4% (mono) | 6.8% (mono) | 6.5% (mono) | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | N=416 | N=91 | N=1157 | N=72 | N=405 | N=111 | N=13 | N=18 | N=129 | N=461 | Not set |
| ?Artama et al 2013 | LBW | - | LBW | LBW | LBW | - | LBW | - | - | LBW | - |
| Not set | 5.2% (all) | Not set | 4.1% (all) | 10.7% (all) | 4.4% (all) | Not set | 3.8% (all) | Not set | Not set | 4.6% (all) | Not set |
| LBW | 4.7% (mono) | Not set | 3.5% (mono) | 15.4% (mono) | 3.6% (mono) | Not set | 3.8% (mono) | Not set | Not set | 4.0% (mono) | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| SGA | SGA | Not set | SGA | SGA | SGA | Not set | SGA | Not set | Not set | SGA | Not set |
| Not set | 2.3% (all) | Not set | 1.7% (all) | 3.6% (all) | 3.9% (all) | Not set | 0 (all) | Not set | Not set | 1.9% (all) | Not set |
| Not set | 1.8% (mono) | Not set | 1.2% (mono) | 0 (mono) | 3.4% (mono) | Not set | 0 (mono) | Not set | Not set | 1.7% (mono) | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | N=1292 (all) | Not set | N=345 (all) | N=56 (all) | N=695 (all) | Not set | N=53 (all) | Not set | Not set | N=944 (all) | Not set |
| Not set | 1084 (mono) | Not set | 173 (mono) | 13 (mono) | 532 (mono) | Not set | 26 (mono) | Not set | Not set | 706 (mono) | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Fujii et al 2013 | Not set | IUGR | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | 3.50% | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| IUGR | Not set | Vs | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | 1.9% control | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| LBW | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | LBW 10.5% | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Vs | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | 4.4% control | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Almgren et al 2009 | -0.15 mean SD +/- 0.03 | -0.02 +/- 0.13 | -0.004 +/-0.06 | - | - | - | -0.02 +/- 0.09 | - | - | -0.10 mean SDs +/- 0.05 | - |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| BW adjusted HC | N=1094 | N=56 | N=308 | Not set | Not set | Not set | N=137 | Not set | Not set | N=460 | Not set |
| Others | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Mostacci et al 2017 | - | 27% | - | - | - | - | 6.30% | - | - | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| SGA | Not set | N=11 | Not set | Not set | Not set | Not set | N=30 | Not set | Not set | Not set | Not set |
| Winterfeld et al 2016 | Not set | Not set | Not set | Not set | Not set | Not set | Not set | 3,300 g (3,000 to 3,690) | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Birth Weight g (median, IQR) | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=119 | Not set | Not set | Not set |
| ?Ornoy et al 2008 | - | - | - | - | - | - | - | - | 2932g | Not set | Not set |
| Birth weight (grams) | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | vs | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | 3300 | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set |
| Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | Not set | N=52 | Not set | Not set |